Triplets

Downloads
  • Regulatory triplets detected in SCENIC+ [coming soon, bundled with preprint]
  • TF activity and TF expression interaction-eQTLs [coming soon, bundled with preprint]
  • Cis Regulatory Element interaction-eQTLs [coming soon, bundled with preprint]
Changelog
2026-06-xx: Initial data release
Genetic variants can rewire control of gene expression.
a. Histogram depicting the number of TFs that are linked to the same target gene through SCENIC+-derived regulatory triplets. A median of 4 TFs are linked to the same target gene. b. Histogram showing the number of chromatin peaks that are linked to the same target gene through SCENIC+-derived regulatory triplets (eRegulon). A median of 6 peaks are linked to the same target gene. c. The proportion of SCENIC+ triplets as part of an eRegulon that overlap with genetic variants associated with a matching 1. dual-QTL (matching peak-gene), 2. eQTL within an accessible peak (matching peak-gene), or 3. caQTL (matching peak). Variants have not been classified in multiple tiers, and have been preferentially classified in a higher tier. d. The types of interaction-eQTLs with TF activity, chromatin accessibility or both. e. caQTL and eQTL regulated by SNP rs4869314 in CD4+ T cells for the region-gene pair that is part of the REL-ERAP2 eRegulon. f. Stimulation-specific interaction of REL-ERAP2 TF activity-i-eQTL. g. We expect the arthritis risk allele (G) of SNP rs4869314 to increase ERAP2 expression by promoting formation of a strongly activating c‑Rel heterodimer complex at the enhancer under basal or CA‑stimulated conditions. In contrast, the non‑risk allele preferentially recruits a weakly activating c‑Rel homodimer. As a result, changes in c‑Rel TF activity produce a larger shift in regulatory complex composition in risk‑allele carriers, i.e. from a strongly activating heterodimer toward a weakly activating homodimer, leading to a stronger negative relationship between c‑Rel activity and ERAP2 expression. #EigenMT multiple testing p-value is provided. EigenMT multiple testing correction was used to overcome permutation instability for the ERAP2 gene.