scRNA-seq cis-eQTLs and co-expression QTLs

This web page accompanies the manuscript titled
'Single-cell RNA sequencing identifies cell type-specific cis-eQTLs and co-expression QTLs. ', by van der Wijst et al, published in Nature Genetics.
For further questions, contact the corresponding author: lude@ludesign.nl


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Figure 2: Most significant co-expression QTL in the CD4+ T cells.

Figure 2 - Most significant co-expression QTL in the CD4+ T cells. (a) The non-imputed expression of RPS26 and RPL21 of all individual CD4+ T cells colored by genotype (left panel) and stratified per SNP rs7297175 genotype (right panels). Genotype- and donor-specific regression lines are shown in the left and right panel, respectively. Each data point represents a single cell. (b) The Spearman’s rank correlation coefficient (r) between RPS26 and RPL21 expression stratified by SNP rs7297175 genotype in the CD4+ T cells per donor. Each data point represents a single donor. Box plots show the median, the first and third quartiles, and 1.5 times the interquartile range. (c) The imputed expression of RPS26 and RPL21 of all individual CD4+ T cells colored by genotype (left panel) and stratified per SNP rs7297175 genotype (right panels). Genotype- and donor-specific regression lines are shown in the left and right panel, respectively. Each data point represents a single cell. (d) The expression of RPS26 and RPL21 of whole blood bulk RNA-seq samples colored by SNP rs7297175 genotype. Genotype-specific regression lines are shown. Each data point represents a single bulk RNA-seq sample.